Following radiation therapy, many cancer patients experience moderate to severe side effects that is a result of the death of the normal tissues such as the skin and internal organs. These side effects may limit the amount of radiation that can be delivered, decreasing the overall effectiveness of the radiation. Reducing or preventing these side effects remain an unmet clinical need. Often times, the side effects may be severe enough that the radiation therapy is disrupted.1,2,3,4 

 

These side effects result when biological systems are exposed to high energy levels such as those produced by radiation exposure. Free radicals (also called Reactive Oxygen Species) are produced at high levels that are then capable of destroying normal tissues. While cells release some protective molecules, the normal cells are not capable of blocking all the oxidation damage caused by the excessive amounts of free radicals, thus resulting in the death of normal tissues.  

 

Some of the select adverse events and damage from radiation therapy experienced by cancer patients are:

 

BREAST - Skin Damage including dryness, discoloration, and blisters (radiodermatitis)

 

COLORECTAL - Damage to the Bowel and Bleeding of the Rectum, Radiodermatitis

 

HEAD AND NECK - Drying of the mouth, loss of saliva, difficulty swallowing and other symptoms (Xerostomia), Radiodermatitis  

 

LUNG - Inflammation and Scarring of the Lungs (Radiation Pneumonitis), Radiodermatitis

 

PROSTATE - Inflammation of Rectum, Frequent and Painful Urination, Radiodermatitis

 

 

BioCurity's technology preclinical testing, some of which is described in some peer-reviewed publications, demonstrate the following:5,6 

 

  • Protection of the skin and internal tissues from radiation-induced damage
  • Improved survival in animals given high doses of radiation
  • No detected toxicity at 1000X the effective dose
  • No interference with effectiveness of radiation on tumors

 

1Siegel, Rebecca, et al. “Cancer Statistics, 2016.” CA Cancer J Clin. 66 (2016): 7-30

2Ryan, Julie. “Ionizing Radiation: The Good, the Bad, and the Ugly”. J Invest Dermatol. 132 (2012): 985-993

3Bray Fleta, et al. “Acute and Chronic Cutaneous Reactions to Ionizing Radiation Therapy.” Dermatol Ther. 6 (2016): 185-206

4Radvansky, Lauren, et al. “Prevention and management of radiation-induced dermatitis, mucositis and xerostomia.” Am J Health Syst Pharm. 12 (2013): 1025-1032

5Colon, Jimmy et al. " Protection from radiation-induced pneumonitis using cerium oxide nanoparticles." Nanomedicine:5 (2009): 25-231

6Baker, Cheryl (2010) Topical Cerium Oxide Nanoparticles unpublished raw data

 

 

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